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Non-Invasive Prenatal Screening Test

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Who is suitable for NIPS testing?

According to a 2015 report in The New England Journal of Medicine (NEJM), NIPS is more accurate than traditional chromosome testing and untrasonic testing for both low and high risk pregnancies.

The mother is advised to undergo NIPS as the first testing method if she (1) is of advanced maternal age, (2) received abnormal blood serum test results, (3) received abnormal ultrasound results, (4) has a history of miscarriage with unclear causes, (5) has a high transposition risk (or the father has a high transposition risk), (6) has a higher risk of placenta previa or early stage hemorrhage, or (7) is pregnant with twins. This will avoid unnecessary invasive testing that has a risk of causing miscarriage, premature delivery, hemorrhage, or amniotic fluid leakage. NIPS is also less likely to yield erroneous results.

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For regular, low risk pregnancies, the mother can undergo NIPS or blood serum screening in the 1st or 2nd trimester.

NIPS is not suitable in cases of where the mother is carrying 3 or more fetuses or if the mother has a history of malignant tumors and/or organ transplantation.

The accuracy of NIPS is lower for twins (90%) than it is for a single fetus.